Why pka is importance

By knowing the pKa of a drug and pH of certain body compartment, you will able to calculate how many drugs will be electrically charged or not, excreted or absorbed by using Henderson—Hasselbalch equation:. How do drugs leave our body system? Drug are usually filtered out by the renal tubule, which is in the kidney. Electrically charged molecules inside can easily slip out, but uncharged molecules are reabsorbed back into the bloodstream and continue affecting your body [4].

To minimize the damage, the doctor might administer medicine that affects the pH of your blood. Eventually, these charged molecules will remain in the renal tubule and pass out of the body through urination.

Hopefully, this explanation of pKa will give you a general idea of how medicine works and a heightened sense of caution when managing your medicine. The first paragraph was engaging and included a good colloquial language for every reader to understand. I do think however you could include a bit more text that goes further into depth about pKa and pH including how they differ in definition with sub headings so the reader is not lost as they read through the blog and look at the diagrams.

You need to have some headings and subheading when you submit the final version. If you do it as a pdf it will be easier to format. Some of your sources are unreliable Ziyao. I would probably expect about twice this amount of text in a 2 page blog so maybe you can develop the ideas a bit more. This is good quality information in the body. Really good salt analogy. With the first diagram, maybe label more so it is easer to understand what it is, what is happening and what is the inside and the outside of the cell??

Develop and improve products. List of Partners vendors. Share Flipboard Email. Anne Marie Helmenstine, Ph. Chemistry Expert. Helmenstine holds a Ph.

She has taught science courses at the high school, college, and graduate levels. Facebook Facebook Twitter Twitter. Updated November 11, A lower pKa value indicates a stronger acid.

That is, the lower value indicates the acid more fully dissociates in water. Featured Video. Cite this Article Format. Helmenstine, Anne Marie, Ph. List of the Strong Acids and Key Facts.

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